Pharmako/Poeia: Plant Powers, Poisons, and Herbcraft includes a new introduction by the author and as in previous editions focuses on familiar psychoactive plant-derived substances and related synthetics, ranging from the licit (tobacco, alcohol) to the illicit (cannabis, opium) and the exotic (absinthe, salvia divinorum, nitrous oxide). Each substance is explored in detail, not only with information on its history, pharmacology, preparation, and cultural and esoteric correspondences, but also the subtleties of each plant's effect on consciousness in a way that only poets can do. The whole concoction is sprinkled with abundant quotations from famous writers, creating a literary brew as intoxicating as its subject.

The Pharmako series is continued in Pharmako/Dynamis (focusing on stimulants and empathogens) and Pharmako/Gnosis (which addresses psychedelics and shamanic plants).

Plant student Dale Pendell established himself as one of the foremost popular exponents of shamanic ethnobotany with his unprecedented Pharmako trilogy. A noted poet, he was the founding editor of the avant-garde magazine Kuksu and a cofounder of the Primitive Arts Institute and has led workshops on ethnobotany and ethnopoetics for the Naropa Institute and the Omega Institute. Pendell was part of the Oracular Madness theme camp at Burning Man for a number of years (his book I nspired Madness: The Gifts of Burning Man was published by Frog Books in 2006). Also an experienced computer scientist, he lives with his wife Laura in California's Sierra foothills.